Product Description
Isopropyl acetate (CAS No. 108-21-4), also known as isopropyl ethanoate, is a volatile ester solvent with excellent dissolving ability and favorable physical properties. It appears as a clear, colorless liquid with a pleasant fruity odor.
Due to its good compatibility with many organic solvents, including alcohols, ketones, and ethers, isopropyl acetate is widely used in solvent systems and industrial formulations. It exhibits moderate water solubility, with approximately 2.9% solubility by weight at 20°C, while maintaining excellent performance in organic applications.
With its combination of strong solvency, rapid evaporation rate, and stable chemical properties, isopropyl acetate is an important solvent material used in coatings, inks, adhesives, cleaning agents, and other specialty chemical applications.
| Melting point | -73 °C |
| Boiling point | 88.8 °C |
| density | 0.872 g/mL at 25 °C(lit.) |
| vapor density | 3.5 (vs air) |
| vapor pressure | 47 mm Hg ( 20 °C) |
| refractive index | n20/D 1.377(lit.) |
| FEMA | 2926 | ISOPROPYL ACETATE |
| Fp | 62 °F |
| storage temp. | Store below +30°C. |
| solubility | 1 M HCl: soluble50mg/mL, clear to slightly hazy, colorless |
| form | Liquid |
| color | Clear colorless |
| Odor | Pleasant, fruity; nonresidual. |
| Odor Threshold | 0.16ppm |
| Odor Type | ethereal |
| biological source | synthetic |
| explosive limit | 1.8%, 37°F |
| Water Solubility | 2.90 g/100 mL |
| FreezingPoint | -73.4℃ |
| Sensitive | Moisture Sensitive |
| JECFA Number | 305 |
| Merck | 145205 |
| BRN | 1740761 |
| Henry's Law Constant | 3.3×10-2 mol/(m3Pa) at 25℃, Brockbank (2013) |
| Exposure limits | TLV-TWA 250 ppm (～950 mg/m3) (ACGIH, MSHA, and OSHA); TLV-STEL 310 ppm (～1185 mg/m3) (ACGIH); IDLH 16,000 ppm (NIOSH). |
| Stability: | Stable. Flammable - note low flash point. Incompatible with strong oxidizing agents, strong acids, nitrates, alkali metals. May attack some plastics and rubber. |
| Cosmetics Ingredients Functions | SOLVENT |
| Cosmetic Ingredient Review (CIR) | Isopropyl acetate (108-21-4) |
| InChI | 1S/C5H10O2/c1-4(2)7-5(3)6/h4H,1-3H3 |
| InChIKey | JMMWKPVZQRWMSS-UHFFFAOYSA-N |
| SMILES | CC(C)OC(C)=O |
| LogP | 1.03-1.18 at 20℃ |
| Surface tension | 21.89mN/m at 298.15K |
| CAS DataBase Reference | 108-21-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Acetic acid, 1-methylethyl ester(108-21-4) |
| EPA Substance Registry System | Isopropyl acetate (108-21-4) |
Safety Information
| Hazard Codes | F,Xi |
| Risk Statements | 11-36/37/38-67-66-36 |
| Safety Statements | 16-26-36-33-29 |
| RIDADR | UN 1220 |
| WGK Germany | 1 |
| RTECS | AI4930000 |
| Autoignition Temperature | 894 °F |
| TSCA | TSCA listed |
| HazardClass | 3 |
| PackingGroup | II |
| HS Code | 29153900 |
| Storage Class | 3 - Flammable liquids |
| Hazard Classifications | Eye Irrit. 2 |
| Flam. Liq. 2 | |
| STOT SE 3 | |
| Hazardous Substances Data | 108-21-4(Hazardous Substances Data) |
| Toxicity | LD50 orally in rats: 6.75 g/kg (Smyth) |
| IDLA | 1,800 ppm |
Applications of Isopropyl Acetate CAS No. 108-21-4
Isopropyl acetate is a versatile ester solvent widely used in coatings, printing, pharmaceuticals, fragrances, and various industrial processes due to its excellent solvency, fast evaporation rate, and pleasant odor.
Coatings and Printing Applications
Isopropyl acetate is commonly used as a solvent in coatings, paints, and printing inks. Its excellent dissolving ability and rapid evaporation characteristics help improve coating performance, drying efficiency, and processing quality.
Pharmaceutical and Chemical Applications
In pharmaceutical manufacturing, isopropyl acetate serves as an effective extraction solvent for separating and purifying active ingredients and chemical compounds. It is also utilized in various chemical processing applications as a reliable organic solvent.
Industrial Processing Applications
Due to its favorable volatility and solvent properties, isopropyl acetate is used as a dehydrating agent and process solvent in industrial production, supporting efficient manufacturing operations.
Fragrance and Specialty Applications
With its mild fruity aroma, isopropyl acetate is also applied as a fragrance ingredient and flavor-related component in selected formulations.
With its excellent compatibility, fast drying performance, and broad application versatility, isopropyl acetate is an important solvent material for coatings, inks, pharmaceuticals, fragrances, and specialty chemical industries.
