Product Description of Meglumine CAS#6284-40-8
Meglumine is a multifunctional amino sugar compound commonly used in pharmaceutical formulations as a counter ion to improve the solubility and stability of active ingredients. Also known as N-methyl-D-glucosamine, it is derived from sorbitol and possesses suitable chemical properties for pharmaceutical salt formation.
The selection of an appropriate counter ion is an important factor in enhancing the dissolution behavior and bioavailability of poorly water-soluble drugs. Meglumine effectively interacts with acidic drug molecules to form more soluble salts, improving formulation characteristics.
Due to its excellent compatibility, reliable safety profile, and solubility-enhancing properties, Meglumine is widely applied in pharmaceutical development, drug formulation, and specialty medicinal preparations.
Meglumine Chemical Properties
| Melting point | 129-131.5 °C (lit.) |
| Alpha | -16.5 º (c=10, H2O, on dry sub) |
| Boiling point | 331.88°C (rough estimate) |
| Density | 1.2669 (rough estimate) |
| Refractive index | -16.5 ° (C=2, H2O) |
| RTECS | LZ4295770 |
| Storage temp | 2-8°C |
| Solubility | H2O: 0.1 g/mL, clear, colorless |
| Form | Crystalline Powder |
| Pka | pKa 9.39(H2O,t =30.0,I=0.05N2)(Approximate) |
| Color | White to almost white |
| PH | 11 (10g/l, H2O, 20℃) |
| Optical activity | [α]20/D 16.5±0.5°, c = 2% in H2O |
| Water Solubility | 100 g/100 mL (25 ºC) |
| Sensitive | Air Sensitive & Hygroscopic |
| Merck | 146,078 |
| BRN | 385906 |
| InChIKey | MBBZMMPHUWSWHV-VZFHVOOUSA-N |
| LogP | -3.370 (est) |
| NIST Chemistry Reference | N-methylglucamine(6284-40-8) |
| EPA Substance Registry System | Meglumine (6284-40-8) |
Safety Information
| Risk Statements | 36/37/38 |
| Safety Statements | 24/25 |
| WGK Germany | 3 |
| F | 2003/10/23 |
| Autoignition Temperature | ~662 °F |
| TSCA | Yes |
| HS Code | 29221980 |
| Toxicity | LD50 orally in Rabbit: > 5000 mg/kg |
Product Application of Meglumine CAS#6284-40-8
Meglumine is widely used in the pharmaceutical and diagnostic fields, particularly as a functional component in contrast media formulations. It can serve as a solubilizing agent, co-solvent, and surfactant aid to improve the dispersion, stability, and formulation performance of diagnostic agents.
In medical imaging applications, Meglumine is commonly incorporated into contrast agent preparations to enhance the solubility and compatibility of active components, helping optimize the quality and effectiveness of diagnostic products.
Due to its favorable physicochemical properties and excellent compatibility, Meglumine is an important pharmaceutical excipient used in the development of diagnostic drugs, contrast media, and other specialized pharmaceutical formulations.
